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tert-Butyldimethylsilyl Trifluoromethanesulfonate 叔丁基二甲基硅基三氟甲磺酸酯

规格: 97%
CAS: 69739-34-0
产品编号: H98338
MDL: MFCD00000405
品牌: INFI
Chemical Nametert-Butyldimethylsilyl Trifluoromethanesulfonate
CAS Number69739-34-0
Synonym (1,1-Dimethylethyl)dimethylsilyl Trifluoromethanesulfonate TBDMS triflate, Trifluoromethanesulfonic acid tert-butyldimethylsilylester TBDMS 三氟甲磺酸酯 三氟甲磺酸叔丁基二甲基硅基酯 Trifluoromethanesulfonic Acid (1,1-Dimethylethyl)dimethylsilyl ester Trifluoromethanesulfonic Acid tert-Butyldimethylsilyl Ester tert-Buty tert-Butyldimethylsilyl triflate 三氟甲烷磺酸叔丁基二甲基甲硅烷酯 三氟甲烷磺酸叔丁基二甲基甲硅烷酯，叔丁基二甲硅基三氟甲磺酸酯 三氟甲磺酸叔丁基二甲硅烷酯;三氟甲烷磺酸叔丁基二甲基硅烷基酯;叔丁基二甲硅烷基三氟甲磺酸酯;TBDMS 三氟甲磺酸酯;叔丁基二甲基硅基三氟甲磺酸酯 叔丁基二甲基硅基三氟甲磺酸酯 叔丁基二甲基硅烷基三氟甲烷磺酸酯 叔丁基二甲硅基三氟甲磺酸酯
PubChem Substance ID87577284
EC Number274-102-0
Beilstein Registry Number2370068
MDL NumberMFCD00000405
Reaxys-RN2370068
Chemical Name Translation叔丁基二甲基硅基三氟甲磺酸酯
LabNetwork Molecule IDLN00011291
InChIKeyWLLIXJBWWFGEHT-UHFFFAOYSA-N
GHS Symbol
WGK Germany3
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
    Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    Precautionary statements
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P304+P340
    • P304+P340+
    • P305+P351+P338
    • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      Packing GroupII
      UN Number 2920
      Risk Statements
      • R10 Flammable 易燃
      • R34 Causes burns 会导致灼伤
      • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
      • R37 Irritating to respiratory system 刺激呼吸道
        Safety Statements
        • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
        • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
        • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
          Storage condition Moisture Sensitive 储存温度 2-8°C 储存温度 2-8°C,充氩保存
          Hazard Codes 8 C
          Hazard Class3/8
        • 常用在顺式-双(链烯基)环氧乙烷上引入大位阻的叔丁基二甲基硅基，促进室温 Cope 重排反应生成 2-CF3-4,5-二氢噁庚英；还可与与硫代坊共同用于促进快速高效的硫族化物-Morita-Baylis-Hillman 反应。
        • {ALF} For general reactions of trialkylsilyl perfluoroalkanesulfonates, see Trimethyl­silyl­ trifluoromethanesulfonate, A12535; reviews: Synthesis, 1 (1982); Adv. Silicon Chem., 1, 189 (1991).
        • {ALF} Has been used in a sequence for the conversion of N-Boc to N-Cbz: Tetrahedron Lett., 26, 5543 (1985). For an alternative method for this transformation, see Benzyl­ 2,2,2-trichloroacetimidate, A12387.
        • {ALF} Treatment of ɑß-unsaturated esters containing a suitably-placed ketone function with the reagent and triethylamine results in tandem intramolecular Michael-aldol reactions to give cyclobutanone derivatives: J. Am. Chem. Soc., 115, 8107 (1993).
        • {TRC} Hua, D.H. et al.L e-ROS Encyc. Reag. Org. Synth., No pp. given (2001); Suzuki, T. et al.: Synthesis, 4, 555 (2001);
        • {ALF} Powerful silylating agent (see Appendix 4) and Lewis acid; compare tert-Butyl­dimethyl­chlorosilane, A13064 and 3429. Silylation of hindered alcohols can be effected with TBDMS-OTf and 2,6-lutidine, where other reagents are unsuccessful: Tetrahedron Lett., 22, 3455 (1981).
          • 69739-34-0 H98338 tert-Butyldimethylsilyl Trifluoromethanesulfonate 叔丁基二甲基硅基三氟甲磺酸酯

          化学属性

          Mol. FormulaC7H15F3O3SSi
          Mol. Weight264
          Refractive index1.3840 to 1.3880
          Boiling Point65-67
          Density1.151
          Flash Point36°C(lit.)
          TSCANo
          Appearance 无色至淡黄色液体。
          Stability对湿度敏感
          pH:A

          *以上化合物性质及应用等信息仅供参考

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