DoMole-安徽敦茂科技

Chlorotrimethylsilane 三甲基氯硅烷

规格: 98%，SpcSeal

CAS: 75-77-4

产品编号: H84142

MDL: MFCD00000502

品牌: INFI

Chemical Name	Chlorotrimethylsilane
Synonym	Chlorotrimethylsilane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	75-77-4
EC Number	200-900-5
Beilstein Registry Number	1209232
MDL Number	MFCD00000502
PubChem Substance ID	6397
Reaxys-RN	1209232
Chemical Name Translation	三甲基氯硅烷
Wiswesser Line Notation	G-SI-1&1&1
LabNetwork Molecule ID	LN00164280
InChI	InChI=1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
Canonical SMILES	C[Si](C)(C)Cl

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1000 mg/kg/I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   54,495,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1780 uL/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 12,574,1993

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USKHAB Uspekhi Khimii. Progress in Chemistry.  For English translation, see
   RCRVAB. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1932-
   Volume(issue)/page/year: 38,2173,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5660 uL/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - other changes
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 12,574,1993

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Immunological Including Allergic - decreased immune response
REFERENCE :

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8(Suppl
   7),1,1986

Signal word	Danger
WGK Germany	1
Safety Statements
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护； S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
R10 Flammable 易燃 R11 Highly flammable 非常易燃 R14 Reacts violently with water 遇水会猛烈反应 R19 May form explosive peroxides 可能生成易爆的过氧化物质 R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害 R21 Harmful in contact with skin 与皮肤接触有害 R34 Causes burns 会导致灼伤 R35 Causes severe burns 会导致严重灼伤 R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性 R37 Irritating to respiratory system 刺激呼吸道 R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。 P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P301+P310 P301+P330+P331+P310 P305+P351+P338 P305+P351+P338+P310 P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。 P370 In case of fire: 在发生火灾的情况下： P370+P378 P403+P233 P403+P235 P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤 H351 Suspected of causing cancer 怀疑致癌 H225 Highly flammable liquid and vapour 高度易燃液体和蒸气 H335 May cause respiratory irritation 可能导致呼吸道刺激 H302 Harmful if swallowed 吞食有害 H226 Flammable liquid and vapour 易燃液体和蒸气 H332 Harmful if inhaled 吸入有害 H315 Causes skin irritation 会刺激皮肤 H318 Causes serious eye damage 严重伤害眼睛 H312 Harmful in contact with skin 皮肤接触有害 H301+H331 H331 Toxic if inhaled 吸入中毒 H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕 H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Personal Protective Equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECS	VV2710000
Packing Group	II
UN Number	1298 2924
Storage condition	+4°C +4℃ 4 4℃ Moisture Sensitive Store at RT. 储存温度2-8℃ 密封阴凉干燥保存,充氩储存,储存温度2-8℃ 密封阴凉干燥保存。
Hazard Codes	3 C T,F,C,Xn
Hazard Class	3/8
Warnings	危化品目录(2015)
Restrict	危险品

用作硅酮油制造的中间体、憎水剂、分析用试剂、聚硅酮液中间体、甲基硅油封头剂、抗水剂。

{ALF} Carbonyl compounds can be converted to their silyl enol ethers, e.g. with triethylamine in DMF: Org. Synth. Coll., 6, 327 (1988); 7, 424 (1990); 8, 460 (1993); or using catalysis with NaI: Org. Synth. Coll., 9, 573 (1998).

{ALF} The conversion of alcohols to alkyl chlorides requires catalysis, e.g. SeO2: J. Org. Chem., 53, 3634 (1988), or by DMSO: J. Org. Chem., 60, 2638 (1995). The same system is also effective in opening epoxides.

{ALF} For further details and reviews, see Appendix 4.

{ALF} For cleavage of ethers, see Sodium iodide, A15480.

{ALF} Conjugated enones give trimethylsilyloxydienes. For examples, see: Org. Synth. Coll., 6, 445 (1988); 7, 282 (1990). TMS chloride, LiBr and trimethylamine in THF is a convenient system for silylation of enones: Acta Chem. Scand., 43, 188 (1989). The same combination converts ɑ- and ß-diketones to their bis silyl enol ethers: Acta Chem. Scand., 43, 304 (1989). See also Trimethylsilyl trifluoromethanesulfonate, A12535.

{uni_hamburg} Short: II/25C

{ALD} Merck: 14,10311

{uni_hamburg} Short: II/14a

{ALF} Silylation at carbon atoms is usually carried out using organometallic reagents, e.g. vinylmagnesium bromide: Org. Synth. Coll., 6, 1033 (1988). In aromatic rings, silyl groups can be introduced by directed metallation, followed by silylation; see e.g.: J. Org. Chem., 49, 4657 (1989). The silyl substituents can readily be replaced by electrophiles, allowing "abnormal" patterns of substitution. See 1,3-Dimethoxybenzene, A13380.

{ALD} Merck: 14,10311

Beilstein:4(3)1857

{uni_hamburg} Short: II/2

{ALF} For facile O-silylation of tertiary alcohols in the presence of Mg metal, see: Synlett, 1025 (2000).

75-77-4 H84142 Chlorotrimethylsilane
三甲基氯硅烷

化学属性

Mol. Formula	C3H9ClSi
Mol. Weight	108.64
Density	0.85
Autoignition Point	752 °F
Refractive index	1.3850 to 1.3900
Vapor Density	3.7 (vs air)
Boiling Point	57 °C(lit.)
Vapor Pressure	100 mmHg ( 25 °C)
Melting Point	−43 - −37 °C(lit.)
Flash Point	104 °F
TSCA	Yes
Solubility	起反应
Stability	对湿度敏感

*以上化合物性质及应用等信息仅供参考

电子化学品

催化剂

配体

有机硅

元素分类

其他精细新材料

Chlorotrimethylsilane 三甲基氯硅烷

规格: 98%，SpcSeal

化学属性

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