Cisplatin 顺铂
规格: 99%,Pt 64.5%
CAS:
15663-27-1
产品编号: H53754
MDL:
MFCD00011623
品牌: INFI
| Chemical Name | cis-Diammineplatinum(II) dichloride |
|---|---|
| Synonym | Platinum, diamminedichloro-, (SP-4-1)- trans-Dichlorodiammine platinum Dichlorodiammineplatinum(II)Transplatin Peyrone's chloride Platidiam cis-Dichlorodiammine platinum(II) Cisplatin cis-DDP Platinum, diamminedichloro-, trans- Cisplatyl Dichlorodiammineplati trans-Dichlorodiammineplatinum(II) cis-Platinum(II) diamminedichloride Transplatin 顺氯氨铂 顺-二氯二氨基铂(II) trans-Dichlorodiamineplatinum(II) trans-DDP Diamminedichloroplatinum cis-Platinous diammine dichloride 顺-二氯二氨基铂(II) 顺式-二胺二氯铂 顺氯氨铂 trans-Dichlorodiammineplatinum(II) 反式-二氨基二氯化铂(II) cis-Platin 顺式-二胺二氯铂 |
| MDL Number | MFCD00011623 |
| PubChem Substance ID | 24871609 |
| EC Number | 239-733-8 |
| CAS Number | 15663-27-1 |
| Merck Number | 2317 |
| Chemical Name Translation | 顺式-二氯二氨基铂 |
| InChIKey | DQLATGHUWYMOKM-UHFFFAOYSA-L |
| Wiswesser Line Notation | Z&2 PT-G2 |
| LabNetwork Molecule ID | LN01250618 |
GHS Symbol
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32408 ug/kg/10W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,4368,1981
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 16 mg/kg/19W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,913,1979
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 16204 ug/kg/10W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,4368,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7500 ug/kg
female 17 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & ChestnutTYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 17900 ug/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Blood - normocytic anemia REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 10,723,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IOBPD3 International Journal of Radiation Oncology, Biology, Physics.
(Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-
1975- Volume(issue)/page/year: 5,1417,1979TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9200 ug/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Blood - normocytic anemia REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/ye
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GTKRDX Gan to Kagaku Ryoho. Cancer and Chemotherapy. (1-8-9 Yaesu, Chuo-ku, Tokyo 103, Japan) V.1-
TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 50 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 127,23,1984
TYPE OF TEST : Micronucleu
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 125 ng/plate REFERENCE : NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 28,159,1985
{hazTYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Mold - Neurospora crassa DOSE/DURATION : 200 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 125,43,1984
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 250 umol/L REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 29,327,1980
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 4 mg/L REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
TYPE OF TEST : Specific locus test TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 50 umol/L REFERENCE : MUREAV Mutation Research. (Else
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 10 mg/kg SEX/DURATION : male 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/p
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 1100 ug/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,122,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 3 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V
| WGK Germany | 3 |
|---|---|
| Precautionary statements | |
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| Signal word | |
| Hazard statements | |
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| RTECS | TP2450000 |
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Safety Statements | |
| |
| Packing Group | II |
| UN Number | UN3288 |
| Risk Statements | |
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| Hazard Codes | T Xn |
| Hazard Class | 6.1 |
化学属性
| Mol. Formula | cis-Pt(NH3)2Cl2 |
|---|---|
| Mol. Weight | 300 |
| Melting Point | 270 |
| Solubility | Soluble in DMF. Insoluble in most common solvents |
| TSCA | No |
| Density | 1.0 |
*以上化合物性质及应用等信息仅供参考
