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2-(Trimethylsilyl)ethanol 2-三甲基硅基乙醇

规格: 95%
CAS: 2916-68-9
产品编号: H73162
MDL: MFCD00002825
品牌: INFI
Chemical Name2-(Trimethylsilyl)ethanol
CAS Number2916-68-9
Alfabeta NameTRIMETHYLSILYLETHANOL 2-
MDL NumberMFCD00002825
Synonym (2-Hydroxyethyl)trimethylsilane
EC Number220-844-5
Beilstein Registry Number1732034
PubChem Substance ID87577204
Reaxys-RN1732034
Chemical Name Translation2-三甲基硅基乙醇
InChIKeyZNGINKJHQQQORD-UHFFFAOYSA-N
Wiswesser Line NotationQ2-SI-1&1&1
LabNetwork Molecule IDLN00009690
InChIInChI=1S/C5H14OSi/c1-7(2,3)5-4-6/h6H,4-5H2,1-3H3
Canonical SMILESC[Si](CCO)(C)C
IUPAC Name2-trimethylsilylethanol
  • 经由相关异氰酸酯的醇解，合成Teoc-protected 胺。也是羧基和磷酸根基团的保护试剂。
  • {ALD} Beilstein:4(4)3951
  • {ALF} Carboxyl groups can be protected as 2-(trimethylsilyl)ethyl (TMSE) esters by carbodiimide coupling: Helv. Chim. Acta, 60, 2711 (1977); J. Org. Chem., 62, 93 (1997), from the acid chloride in pyridine: Helv. Chim. Acta, 60, 3039 (1977), or refluxing the acid in THF in the presence of TMS chloride: J. Am. Chem. Soc., 106, 3030 (1984). The TMSE protecting group is useful in peptide synthesis. Cleavage is readily effected with TBAF in DMF or DMSO: Helv. Chim. Acta, 60, 2711 (1977); Bioorg. Med. Chem. Lett., 3, 437 (1993).
  • {PUB} ChEMBL|Crystallography Open Database (COD)|PubChem --- Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position. --- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072467
  • {PUB} ChEMBL|PubChem --- Effects of charge, volume, and surface on binding of inhibitor and substrate moieties to acetylcholinesterase --- https://pubmed.ncbi.nlm.nih.gov/4032433
  • {PUB} Crystallography Open Database (COD)|PubChem|The Cambridge Structural Database --- 2-[2-(Trimethyl-silyl)eth-yl]isoindoline-1,3-dione --- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980030
  • {PUB} Crystallography Open Database (COD)|PubChem|The Cambridge Structural Database --- A total synthesis of milbemycin G: approaches to the C(1)–C(10)-fragment and completion of the synthesis --- https://pubmed.ncbi.nlm.nih.gov/16211101
  • {PUB} Nature Chemistry|PubChem|Springer Nature --- Enantioselective iron-catalysed O-H bond insertions. --- https://pubmed.ncbi.nlm.nih.gov/20571572
  • {PUB} PubChem --- A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds --- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225090
  • {PUB} PubChem --- An efficient and highly selective deprotecting method for beta-(trimethylsilyl)ethoxymethyl ethers --- https://pubmed.ncbi
    • 2916-68-9 H73162 2-(Trimethylsilyl)ethanol 2-三甲基硅基乙醇

    化学属性

    Mol. FormulaC5H14OSi
    Mol. Weight118.25
    Boiling Point145°C at 760 mmHg
    Density0.825
    Refractive index1.4230 to 1.4250
    Flash Point56 °C - 闭杯
    TSCANo
    Solubility可溶
    Melting PointN/A

    *以上化合物性质及应用等信息仅供参考

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