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Bis(2-oxo-3-oxazolidinyl)phosphinic chloride 二(2-氧代-3-唑烷基)次膦酰氯

规格: 97%

CAS: 68641-49-6

产品编号: H78250

MDL: MFCD00010077

品牌: INFI

Chemical Name	Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
MDL Number	MFCD00010077
Synonym	BOP-Cl Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic Chloride 双(2-氧代-3-噁唑烷基)次磷酰氯双（2-氧代-3-恶唑烷基）次磷酰氯
CAS Number	68641-49-6
Beilstein Registry Number	87564149
PubChem Substance ID	87564149
EC Number	250-023-7
Reaxys-RN	3654596
Chemical Name Translation	二(2-氧代-3-唑烷基)次膦酰氯
InChIKey	KLDLRDSRCMJKGM-UHFFFAOYSA-N
LabNetwork Molecule ID	LN00009083

多肽缩合剂。适宜于因有空间位阻而不能与碳二亚胺类缩合剂反应的情形。

{ALF} For use in the direct selective 5'-acylation of nucleosides by carboxylic acids, (without 3'-protection), see: Tetrahedron, 44, 229 (1988). For high yield dehydration of carboxylic acids to anhydrides, see: Synthesis, 616 (1981). Also used in macrolide cyclization: J. Am. Chem. Soc., 104, 6818 (1982), and in formation of acyclic esters: Synth. Commun., 14, 515 (1984).

{ALF}

{ALF} Coupling reagent for which the rates of reaction with various nucleophiles are sufficiently different to permit a genuine "one-step" coupling of carboxylic acids with amines: Synthesis, 547 (1980). Particularly suitable for coupling N-alkyl amino acids: J. Org. Chem., 51, 3350 (1986). For discussion of strategies for one-step coupling in synthesis of amides, see: Synthesis, 413 (1984), and of the scope and limitations of the reagent in peptide coupling, see: Int. J. Pept. Prot. Res., 29, 574 (1987); J. Org. Chem., 55, 2895 (1990). See also Appendix 6.

{ALF} The mixed anhydride formed with carboxylic acids adds to imines to give ß-lactams: Synthesis, 63 (1982):

{ALF} These are also formed in high yield by cyclization of ß-amino acids: Bull. Korean Chem. Soc., 12, 457 (1991).

68641-49-6 H78250 Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
二(2-氧代-3-唑烷基)次膦酰氯

化学属性

Mol. Formula	C6H8ClN2O5P
Mol. Weight	255
Melting Point	191
TSCA	No
Density	1.71
Stability	易吸潮

*以上化合物性质及应用等信息仅供参考

电子化学品

催化剂

配体

有机硅

元素分类

其他精细新材料

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride 二(2-氧代-3-唑烷基)次膦酰氯

规格: 97%

化学属性

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