• QQ: 1811068585
  • Hotline: +86 13275595566

N,O-Bis(trimethylsilyl)acetamide N,O-双(三甲基硅烷基)乙酰胺

规格: 95%
CAS: 10416-59-8
产品编号: H67855
MDL: MFCD00008270
品牌: INFI
Chemical NameN,O-Bis(trimethylsilyl)acetamide
CAS Number10416-59-8
Alfabeta NameBISTRIMETHYLSILYLACETAMIDE NO()-,
MDL NumberMFCD00008270
Synonym BSA N,O-双(三甲基甲硅烷基)乙酰胺 Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester BSA HMDS TMCS in pyridine TMCS pyridine Trimethylsilyl N-trimethylsilylacetamidate; BSA; Dynasylan BSA Bis(trimethylsilyl)acetamide (BSA)/trimethylchlorosilane (TMCS) Bis(trimethylsilyl)acetamide HMDS N,O-Bis(trimethylsilyl)acetamide - Trimethylchlorosilane Mixture pentafluorobenzoyl chloride N,O-双(三甲基硅烷基)乙酰胺 N-(Trimethylsilyl)acetimidic acid, trimethylsilyl ester N,O-双三甲硅基乙酰胺
Reaxys-RN2206090
PubChem Substance ID87576562
EC Number233-892-7
Beilstein Registry Number1306669
Chemical Name TranslationN,O-双三甲硅基乙酰胺
Wiswesser Line Notation1-SI-1&1&OY1&UN-SI-1&1&1
LabNetwork Molecule IDLN01745639
  • 中性硅烷化保护剂 ,BSA产品是重要的医药中间体,主要用于合成孢头抗生素的生产。
  • {ALF} O-Silylation in the presence of TBAF (0.02 equiv.) occurs under very mild conditions: Tetrahedron Lett., 35, 8409 (1994).
  • {ALF} BSA catalyzes the acylation of acylphosphoranes with activated derivatives of carboxylic acids. Subsequent ozonolysis, or oxidation with singlet oxygen or dimethyldioxirane, provides a route to 1,2,3-triketones: J. Org. Chem., 54, 2785 (1989); 60, 8231 (1995):
  • {SNA}
  • {ALF} Powerful silylation reagent for a wide range of functional groups under mild conditions. See Appendix 4. Reviews: J. Prakt. Chem./ Chem. Ztg., 337, 332 (1995); Synthesis, 357 (1998). Unlike halosilanes, silylated amides often need no added base catalysts. For an example of use without added solvent or catalyst for the silylation of a tertiary ɑ-hydroxy ketone, see: Org. Synth. Coll., 7, 381 (1990). Silylating power can be increased in polar solvents such as DMF or acetonitrile, or by addition of acidic catalysts, often TMS chloride, or an acid such as TFA or HCl.
  • 10416-59-8 H67855 N,O-Bis(trimethylsilyl)acetamide
N,O-双(三甲基硅烷基)乙酰胺

    化学属性

    Mol. FormulaC8H21NOSi2
    Mol. Weight203
    Refractive index1.4140 to 1.4180
    Density0.812
    Flash Point53 °F
    TSCAYes
    Boiling Point71-73 °C 35 mm Hg(lit.)
    Melting Point21 - 27 °C
    Stability对湿度敏感

    *以上化合物性质及应用等信息仅供参考